KMID : 1134820150440071090
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Journal of the Korean Society of Food Science and Nutrition 2015 Volume.44 No. 7 p.1090 ~ p.1099
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Isolation and Identification of ¥á-Glucosidase Inhibitors from Morus Root Bark
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Jang Yeong-Jung
Leem Hyun-Hee Jeon Young-Hee Lee Dong-Hee Choi Sang-Won
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Abstract
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Among the four different parts of mulberry (Morus alba L.) tree, ethanol extract of Morus root bark showed the highest ¥á-glucosidase inhibitory activity (IC50=12.01 ¥ìg/mL). Bioassay-guided fractionation of the ethanolic extract of root bark by Diaion HP-20, silica gel, ODS-A, and Sephadex LH-20 column chromatographies led to the isolation of four compounds, including Compound (Comp.) 1 (IC50=5.22 ¥ìg/mL), Comp. 2 (IC50=1.78 ¥ìg/mL), Comp. 3 (IC50=2.94 ¥ìg/mL), and Comp. 4 (IC50=1.54 ¥ìg/mL) with strong ¥á-glucosidase inhibitory activities. Their chemical structures were elucidated as morusin (Comp. 1), kuwanon H (Comp. 2), chalcomoracin A (Comp. 3), and chalcomoracin B (Comp. 4) by UV and NMR spectral analyses. These results suggest that prenylflavonoid and mulberrofuran of Morus root bark may be useful as potential therapeutic agents for diabetes.
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KEYWORD
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Morus root bark, ¥á-glucosidase inhibitors, morusin, kuwanon H, chalcomoracin A & B
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